Holding Strong, Healing Naturally™:
Click above to view animation of how TissuGlu Surgical Adhesive* works.

A New Platform Adhesive Technology

Strong. Resorbable. Biocompatible.

Cohera Medical’s novel technology platform has been used to create one-part synthetic adhesives and sealants with a unique chemical composition that cures in the presence of moisture. The adhesives and sealants are resorbable, safe for internal use, and use no human or animal based ingredients. Researchers at Cohera Medical have developed this platform technology to serve the needs of surgeons in multiple disciplines who have long sought simple to use adhesives and sealants that are strong enough to hold tissues together yet biocompatible and not associated with adverse tissue responses.

Holds tissues together to facilitate natural healing processes

Cohera Medical’s adhesive technology has shown shear strength that is similar to external adhesives, and forms a bond that has five times the holding strength of fibrin-based sealants.1

No introduction of animal or human ingredients

Cohera Medical’s technology is fully synthetic. These biocompatible adhesives and sealants are composed primarily of lysine, an essential amino-acid, a chemical design unlike other products on the market today.

Tissues heal naturally

The products are designed to hold tissues together as the natural healing process occurs and then are resorbed by the body after degrading into harmless subcomponents.

Not associated with foreign body response

Because of the unique chemical design, the products are non-toxic, safe and biocompatible for internal use.

Save time in the operating room

The adhesive and sealant technologies are synthesized as a single component that does not begin curing until it is applied to tissue. The products require no mixing and so will not clog during application. The ergonomically designed, single-use applicator allows for ease of use.

Small changes in the platform’s chemical formulation could lead to product line extensions for a variety of surgical indications, including soft tissue fixation, sealants, mesh fixation, and small bone approximation.

Our first commercial product, TissuGlu® Surgical Adhesive, is an adhesive for internal use which secures flaps of tissue in order to reduce fluid accumulation in the wound and eliminate the need for drains in a wide range of surgical procedures. It is indicated in the European market for the approximation of tissue layers where subcutaneous deadspace exists between the tissue planes in large flap surgical procedures such as abdominoplasty.*

The future

Cohera Medical researchers have also developed Sylys® Surgical Sealant, which is designed to help prevent leaks after gastrointestinal anastomoses. Other areas of active development include adhesives for securing implantable devices such surgical mesh for hernia fixation and gynecologic procedures.


  1. Data on file.

*Disclaimer: TissuGlu Surgical Adhesive received European CE Mark in 2011. Currently, TissuGlu Surgical Adhesive is approved for investigational use only in the United States and is not approved for sale or marketing in the U.S. or any other country outside of the EU.

Disclaimer: These products are not currently available for sale or distribution and have not been approved by the U.S. FDA or any other country’s regulatory authority. The devices described are currently limited to non-human investigational use only.