A simple solution for sealing colonic and small bowel anastomoses.
Cohera Medical is developing Sylys™ Surgical Sealant, a single-part
synthetic sealant designed as an adjunct to standard closure techniques to help surgeons performing colorectal procedures to reduce
the incidence of anastomotic leakage following bowel repair.*
Sylys™ Surgical Sealant Technology Animation
Sylys Surgical Sealant will be based upon similar lysine-derived urethane technology Cohera Medical researchers used with their first successful product, TissuGlu® Surgical Adhesive†, currently available in Europe for abdominoplasty and other plastic surgery procedures.
Anastomotic leakage rates following colon resection range on average from 3-15%.1 Such leakage is considered the most serious complication of bowel repair, causing one third of mortalities occurring after colorectal surgery. There is a high clinical and economic need for a product that effectively reduces anastomotic leakage rates, due to the following:
- Leaking anastomoses double the length of stay and increase mortality rates as much as ten-fold1
- Reoperation rates after leakage can be as high as 87%1
- Beyond the initial mortality risk, overall five year survival rates for patients with anastomotic leakage are reduced by 20%1
- Anterior rectal resections have the highest leakage rate, up to 24%1
- Crohn’s disease patients carry a significant risk of anastomotic dehiscence (12%) even when macroscopically normal margins are obtained1
Cohera Medical’s Sylys Surgical Sealant will be one of the first synthetic resorbable sealants to fill this clinical need.
- Kirchoff et al., Complications in colorectal surgery: risk factors and preventative strategies. Patient Safety in Surgery 4:5 (2010)
*Disclaimer: This product is not currently available for sale or distribution and has not been approved by the U.S. FDA or any other country’s regulatory authority. The device described is currently limited to non-human investigational use only.
†Disclaimer: TissuGlu Surgical Adhesive received European CE Mark in 2011. Currently, TissuGlu Surgical Adhesive is approved for investigational use only in the United States and is not approved for sale or marketing in the U.S. or any other country outside of the EU.