Bowel Sealant

A simple solution for sealing colonic and small bowel anastomoses.

Cohera Medical is developing FlexSil™ Surgical Sealant, a single-part
synthetic sealant designed as an adjunct to standard closure techniques to
help surgeons performing colorectal procedures to reduce
the incidence of anastomotic leakage following bowel repair.*

FlexSil Surgical Sealant will be based upon technology similar to the lysine-derived urethane that Cohera Medical researchers used with their first successful product, TissuGlu® Surgical Adhesive^†, currently available in Europe for abdominoplasty and other plastic surgery procedures.

Anastomotic leakage rates following colon resection range on average from 3-15%.¹ Such leakage is considered the most serious complication of bowel repair, causing one third of mortalities occurring after colorectal surgery. There is a high medical and economic need for a product that effectively reduces anastomotic leakage rates, due to the following:

• Leaking anastomoses double the length of stay and increase mortality rates as much as ten-fold¹
• Reoperation rates after leakage can be as high as 87%¹
• Beyond the initial mortality risk, overall five year survival rates for patients with anastomotic leakage are reduced by 20%¹
• Anterior rectal resections have the highest leakage rate, up to 24%¹
• Crohn’s disease patients carry a significant risk of anastomotic dehiscence (12%) even when macroscopically normal margins are obtained¹

Cohera Medical’s FlexSil Surgical Sealant will be one of the first synthetic resorbable adhesive to fill this clinical need.