TissuGlu® Surgical Adhesive

A new era for surgical adhesives.

TissuGlu® Surgical Adhesive* is a lysine-derived urethane adhesive with a unique chemical composition that cures in the presence of moisture. The adhesive is resorbable, biocompatible for internal use, uses no human or animal based ingredients and forms a bond between tissue layers that is five times stronger than any other product available today for this indication.¹

Cohera Medical, Inc.^® researchers developed TissuGlu Surgical Adhesive to serve the needs of plastic and aesthetic surgeons who perform abdominoplasty (tummy tuck) and other procedures that require the creation of large planar flaps of tissue. It is indicated in the European market for the approximation of large flap surgical tissues.

Reduced need for surgical drains.²

TissuGlu Surgical Adhesive helps to reduce fluid accumulation by reducing dead space in the surgical wound. The adhesive holds tissue layers together in close approximation and resists shearing forces by forming a bond that surpasses that of fibrin-based sealants by a multiple of five.¹

Incidence of seroma

By helping to reduce the accumulation of wound exudate in procedures such as abdominoplasty (tummy tuck) that require the creation of large planar flaps of tissue, TissuGlu Surgical Adhesive may also reduce the risk of seroma formation and other complications associated with post-surgical fluid accumulation.

Clinical Study Results: Mean total Drain Volume

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  In a multicenter, prospective randomized trial comparing patients treated with TissuGlu Surgical Adhesive to a control group, patients in the control group experienced a 45% higher mean total drain volume compared to the treatment group (303.5 ± 240.8 mL vs. 208.7 ± 138.23 mL; p = 0.14).¹

Patient follow-up visits

By helping to reduce post-surgical fluid build-up following abdominoplasty (tummy tuck) procedures, TissuGlu Surgical Adhesive may reduce the time interval to drain removal and help patients avoid multiple follow up visits for drain related complications, including interventions to aspirate accumulated fluids.

Potential shorter hospital stays

Use of TissuGlu Surgical Adhesive may contribute to reduced hospital length of stay by helping to reduce the average length of time to drain removal for patients undergoing abdominoplasty (tummy tuck) procedures.

Potential increased patient satisfaction

Use of TissuGlu Surgical Adhesive may reduce the need for uncomfortable and inconvenient post-operative drains and the interventions that are subsequent to fluid accumulation following abdominoplasty (tummy tuck) procedures. Time to ambulation after surgery may be reduced, due to the earlier removal of drains.

Simple, fast and easy application.

TissuGlu Surgical Adhesive stores at room temperature, requires no mixing and comes prepackaged in an ergonomic applicator featuring a Multi-Tip™ Pivoting Head that facilitates rapid application.

Bonding strength comparison

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  The bond formed by TissuGlu Surgical Adhesive is significantly stronger than fibrin or PEG-based products and has equivalent strength to topical cyanoacrylate adhesives.¹

Curing Strength Curve

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  TissuGlu Surgical Adhesive begins to cure immediately when exposed to moisture in the body, achieving a strong bond in 20 minutes, and is fully cured in less than an hour.

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