Sylys® Surgical Sealant

A Revolutionary Solution Designed to Help Reduce Anastomotic Leakage After Gastrointestinal Surgeries.

Sylys® Surgical Sealant is an elastic, resorbable, synthetic sealant designed to help reduce anastomotic leakage in gastrointestinal surgical procedures. Used in conjunction with standard anastomotic closure techniques such as sutures or staples, Sylys protects the suture or staple line, supporting the anastomosis during the first few days of healing when leaks are most likely to occur.

Designed for Surgeons

Cohera Medical, Inc.® researchers developed Sylys Surgical Sealant to serve the needs of colorectal, bariatric and general surgeons who perform gastrointestinal anastomotic procedures. Sylys is designed to improve patient outcomes by helping reduce the likelihood of postsurgical complications from leakage, thereby providing surgeons the best possibility for a successful procedure.

Addresses a Serious Clinical Need

Anastomotic leakage rates following colon resection range on average from 3-15%.1 Such leakage is considered the most serious complication of bowel repair, causing one third of mortalities occurring after colorectal surgery. There is a high clinical and economic need for a product that effectively reduces anastomotic leakage rates, due to the following:

  • Leaking anastomoses double the length of stay and increase mortality rates as much as ten-fold
  • Reoperation rates after leakage can be as high as 87%
  • Beyond the initial mortality risk, overall five year survival rates for patients with anastomotic leakage are reduced by 20%
  • Anterior rectal resections have the highest leakage rate, up to 24%
  • Crohn’s disease patients carry a significant risk of anastomotic dehiscence (12%) even when macroscopically normal margins are obtained

Cohera Medical’s Sylys Surgical Sealant will be the first synthetic resorbable sealant to fill this clinical need.

The First Synthetic Resorbable Sealant: Click above to view Sylys® Surgical Sealant animation.


  1. Kirchoff et al., Complications in colorectal surgery: risk factors and preventative strategies. Patient Safety in Surgery 4:5 (2010)