TissuGlu® Surgical Adhesive

TissuGlu® Surgical Adhesive is the only FDA approved, high-strength synthetic surgical adhesive designed for internal use. TissuGlu forms a strong bond between tissue layers after abdominoplasty, helping to hold tissue in place to facilitate healing. TissuGlu is a clinically proven, safe alternative to postoperative surgical drains in most abdominoplasty patients. 

High Strength – More than 10x the strength of a fibrin sealant.

By forming a strong bond between tissue planes and reducing dead space in the surgical wound, TissuGlu Surgical Adhesive helps improve healing and can eliminate the need for drains in most abdominoplasty patients.

Single Component, No mixing, No thawing.

The adhesive begins as a prepolymer. The adhesive cures in the presence of moisture in the tissue, cross-linking with itself and with the tissue surface to form a strong bond between layers. This means there is no mixing required, and no clogging of the applicator during application.


The cured adhesive forms a network of large polymeric chains that allows the adhesive to remain soft and flexible while also creating a strong tissue bond. As tissues continue to heal, the adhesive eventually breaks down into safe, absorbable subcomponents.

A clinically proven safe alternative to drains.

Currently, most patients who undergo large flap procedures have drains inserted to remove fluid that accumulates under the skin at the surgical site. Drains are often uncomfortable for the patient and can lead to additional complications. TissuGlu Surgical Adhesive forms a strong bond between tissue layers, helping to reduce the space where fluid can accumulate during healing.

Cohera Medical’s recently completed ‘No Drain’ clinical study supports that TissuGlu Surgical Adhesive can eliminate the need for drains in most abdominoplasty procedures. In the clinical trial, when TissuGlu Surgical Adhesive was used, patients required fewer postoperative treatments and resumed normal activities, such as going to work, showering and using the stairs, more quickly.

TissuGlu® Surgical Adhesive Introduction Animation